Hollywood mogul Harvey Weinstein has been charged in New York with rape and several other counts of sexual abuse involving two separate women.
Mr Weinstein had earlier turned himself in to police in the city.
Dozens of women have made allegations, including of rape and sexual assault, against the 66 year old.
Mr Weinstein has always denied non-consensual sex and these are the first charges that have been levelled against him.
A statement from the New York Police Department said Mr Weinstein “was arrested, processed and charged with rape, criminal sex act, sex abuse and sexual misconduct for incidents involving two separate women”.
The statement thanked “these brave survivors for their courage to come forward and seek justice”.
Details of the allegations and of those making the accusations have not yet been released.
The allegations against Mr Weinstein triggered the #MeToo movement, which sought to demonstrate and draw attention to the widespread prevalence of sexual abuse and harassment.
Who else has accused Mr Weinstein?
The Hollywood mogul has faced accusations of sexual harassment and assault from dozens of women. Some have alleged rape.
Actresses Kate Beckinsale, Lysette Anthony and Gwyneth Paltrow are among the high-profile figures to have spoken out.
Actress Ashley Judd is suing the 66-year-old Hollywood producer, claiming he damaged her career after she rejected his sexual advances.
One of the cases was in New York, where Italian model Ambra Battilana accused Mr Weinstein of groping her in 2015.
Investigators decided not to charge him even though there was an audiotape of Mr Weinstein accepting he had touched her breasts and pledging not to do so again.
Prosecutors in Los Angeles are reviewing several cases involving accusations against Weinstein after police investigations.
London’s Metropolitan Police are also assessing a sexual abuse allegation against Mr Weinstein.
What has happened to the film producer?
The allegations have left his career in tatters.
He was fired last year from his production firm the Weinstein Company, which later filed for bankruptcy.
Top industry figures have condemned him and the organisation behind the Oscars expelled him.
How have people reacted to the latest news?
Some of Mr Weinstein’s accusers have spoken out to welcome the charges.
Actress Rose McGowan wrote that some women had given up hope he would be held accountable.
She said: “Twenty years ago, I swore that I would right this wrong. Today we are one step closer to justice.”
Italian actress Asia Argento, who alleges Mr Weinstein sexual assaulted her in the 1990s, reflected on the latest news in a simple tweet:
What has the Weinstein case inspired?
The #MeToo campaign against sexual harassment and abuse swept through Hollywood last autumn.
It followed an invitation from actress Alyssa Milano on Twitter for those who had been sexually harassed or assaulted to reply “Me Too”. She received half a million responses in 24 hours.
In January, more than 300 actresses, writers and directors launched the Time’s Up project, raising $21m (£15m) in just a month to fund legal assistance for people who suffer harassment, abuse or assault at work.
More cases come to light seemingly every week.
Harvey Weinstein charged with rape in New York