The Week 4 NFL slate is stacked with great matchups. Our NFL Nation reporters bring us the keys to every game, a bold prediction for each matchup and final score predictions.

Additionally, ESPN Stats & Information research provides a stat to know, and the Football Power Index (FPI) goes inside the numbers with a matchup rating (on a scale of 1 to 100) and a game projection. ESPN Fantasy‘s Kyle Soppe and ESPN Chalk‘s Mackenzie Kraemer hand out helpful nuggets as well. It’s all here to help get you ready for a loaded weekend of NFL football.

Let’s get into the full Week 4 schedule, starting with two matchups of undefeated teams.

Jump to a matchup:

Thursday: PHI 34, GB 27
Bye: NYJ, SF

Chiefs (3-0) at Lions (2-0-1)

1 p.m. ET | Fox
Matchup rating: 81.4 | Spread: KC -6.5 (54.5)

What to watch for: Patrick Mahomes hasn’t played in a dome as a pro, and playing indoors at Ford Field should make Kansas City’s offense somehow more dangerous. If Lions cornerbacks Darius Slay and Rashaan Melvin are not at full strength, Mahomes and the Chiefs could be extra special on Sunday. — Michael Rothstein

Bold prediction: Travis Kelce will catch a couple of touchdown passes. Kelce has only one this season, and Detroit has done a nice job of defending tight ends, giving up only seven completions. But the Lions have also given up 93 yards on those passes, and they haven’t faced a tight end with Kelce’s ability. — Adam Teicher

Stat to know: According to ESPN’s coverage analysis using NFL Next Gen Stats research, Mahomes is averaging 12.5 yards per attempt with six passing touchdowns when facing zone coverage this season, both of which are the best in the NFL. But the Lions have used man coverage on 68% of their snaps this season, the third most of any team this season.

What to know for fantasy: Mahomes had the greatest fantasy season ever by a quarterback last season. But if he scores 28.5 points Sunday, he will actually be ahead of where he was through four games in 2018. See Week 4 rankings.

Betting nugget: Matthew Stafford is 9-16 against the spread (ATS) in his career as a home underdog. Read more.

Teicher’s pick: Chiefs 33, Lions 24
Rothstein’s pick: Chiefs 38, Lions 27
FPI prediction: KC, 70.2% (by an average of 7.4 points)

Matchup must-reads: Lions’ Diggs: Mahomes could ‘break every record’Why WR Jones’ reemergence means good things for the Lions’ offenseHardman gives Chiefs another speedy toy for MahomesIn facing Kelce, Lions can learn from containing Ertz

Patriots (3-0) at Bills (3-0)

1 p.m. ET | CBS
Matchup rating: 73.5 | Spread: NE -7.5 (42.5)

What to watch for: Josh Allen has yet to turn in four quarters of mistake-free football this season, but he’ll need to against the Patriots. A large part of his game is his ability to improvise. Whether he’ll be able to make smart improvisational decisions against an opportunistic New England defense will determine how successful the Bills’ offense will be Sunday. — Marcel Louis-Jacques

Bold prediction: Sony Michel will lead the way on offense for New England, as the Patriots’ running game will find its groove after three outings in which the attack has trended more toward the pass. Michel, who has totaled only 108 rushing yards over three games, will top the 100-yard mark in a close contest that will be decided in the fourth quarter. — Mike Reiss

Stat to know: New England has won 17 consecutive games against first- or second-year starting quarterbacks. And the Patriots’ man defense could spell trouble for Allen. According to ESPN coverage metrics powered by NFL Next Gen Stats data, the Patriots use man coverage at the second-highest rate in the league (68%), and Allen averages just 6.6 yards per attempt versus man, compared with 8.0 yards per attempt versus zone.

What to know for fantasy: Tom Brady has failed to score more than 15.6 fantasy points in each of his past four games against the Bills. See Week 4 rankings.

Betting nugget: Last season, New England was 1-5 outright as a single-digit road favorite, including 0-3 outright when favored by 6-9 points on the road. Read more.

Reiss’ pick: Patriots 20, Bills 17
Louis-Jacques’ pick: Patriots 21, Bills 13
FPI prediction: NE, 75.3% (by an average of 9.5 points)

Matchup must-reads: Belichick’s expanded oversight boosts Patriots’ DAllen’s knack for extending plays a blessing and curse for BillsPatriots holding on during roller-coaster ride at wide receiver

Titans (1-2) at Falcons (1-2)

1 p.m. ET | CBS
Matchup rating: 69.1 | Spread: ATL -4 (46)

What to watch for: How the Falcons’ receivers perform against the Tennessee secondary will be key. If Jacksonville’s Gardner Minshew was able to connect downfield on the Titans, surely Matt Ryan can do the same. Keep an eye on Calvin Ridley, who vowed not to let a hip injury hold him back. He had only one target last weekend, and offensive coordinator Dirk Koetter wants to get him more involved. — Vaughn McClure

Bold prediction: Outside linebacker Harold Landry will have two sacks. He has been relatively quiet, having posted only one sack through three games, but he’ll get home against the Falcons with Ryan waiting for the deep routes to develop with his receivers. — Turron Davenport

Stat to know: Julio Jones has a receiving touchdown in seven consecutive games, the longest active streak in the NFL. A.J. Green (nine in 2012), Antonio Brown (eight in 2018) and Wes Welker (eight in 2012 and ’13) are the only players with eight-game streaks over the past 10 seasons.


Rob Ninkovich feels this is a must-win game for Marcus Mariota and the Titans, because if they lose, Mariota could be replaced.

What to know for fantasy: Since Week 13 of last season, Derrick Henry has run for 11 touchdowns. No other player has more than seven. And over that stretch, only Christian McCaffrey has more fantasy points among running backs. See Week 4 rankings.

Betting nugget: Atlanta has failed to cover in 12 consecutive games against AFC opponents, including the Week 3 loss against Indianapolis. The Falcons are 5-21 ATS in their past 26 games against AFC opponents, including 4-14 ATS under Dan Quinn. Read more.

Davenport’s pick: Falcons 28, Titans 20
McClure’s pick: Falcons 31, Titans 17
FPI prediction: ATL, 54% (by an average of 1.4 points)

Matchup must-reads: Who’s to blame for NFL-high 17 sacks on Mariota?DB Allen: Falcons’ defense needs discipline, not Superman

Browns (1-2) at Ravens (2-1)

1 p.m. ET | CBS
Matchup rating: 55.9 | Spread: BAL -6.5 (45)

What to watch for: The Ravens’ offensive line could have problems against the Browns’ pass rush, which is the best Baltimore has played this season “by a long way,” according to coach John Harbaugh. Lamar Jackson is averaging 99 yards rushing per game in his five regular-season starts at Baltimore’s M&T Bank Stadium, but how will the pass rush affect that part of his game? — Jamison Hensley

Bold prediction: Two of Baker Mayfield‘s former Oklahoma teammates, Marquise Brown and Mark Andrews, score touchdowns as Jackson prevails in a shootout of former Heisman Trophy-winning QBs. — Jake Trotter

Stat to know: The Ravens have blitzed on 47% of opposing QB dropbacks this season, the highest mark in the NFL. And they boast the NFL’s fourth-best pass rush win rate, beating blocks within 2.5 seconds 58% of the time, per NFL Next Gen Stats research.

What to know for fantasy: Nick Chubb has the chance to join Todd Gurley as the only players since 2009 to have at least 17 carries and three receptions in each of their teams’ first four games of a season (Gurley did it in 2018). See Week 4 rankings.

Betting nugget: Last season, Baltimore failed to cover in all five divisional games in which it was the favorite, including both tries against Cleveland. Read more.

Trotter’s pick: Ravens 31, Browns 27
Hensley’s pick: Ravens 28, Browns 27
FPI prediction: BAL, 72.7% (by an average of 8.4 points)

Matchup must-reads: Jackson reaching historic heights (just don’t bring it up)Saban, Parcells, car sales? Inside Kitchens’ road map to ClevelandEarl Thomas says Ravens got tired of Browns hype

Panthers (1-2) at Texans (2-1)

1 p.m. ET | Fox
Matchup rating: 54.7 | Spread: HOU -4 (47.5)

What to watch for: The Texans haven’t allowed a player to rush for more than 100 yards since Week 17 of the 2017 season, the third-longest active streak in the NFL, according to ESPN Stats & Information research. Can Panthers running back Christian McCaffrey, who has more than 100 rushing yards in two of three games this season, break that streak? — Sarah Barshop

Bold prediction: Carolina quarterback Kyle Allen will follow his four-touchdown pass performance against Arizona with three against Houston, which has given up only five touchdown passes in three games. He’ll also top 250 yards passing against a defense that is stingy against the run. — David Newton

Stat to know: The Panthers’ defense is using zone coverage on 72% of its snaps in 2019, the second-highest rate in the NFL. And the unit is giving up a league-low 4.6 yards per play this season in that coverage, per ESPN’s coverage metrics powered by NFL Next Gen Stats data.

What to know for fantasy: Allen has made two starts in his NFL career, resulting in seven total touchdowns and a pair of top-7 fantasy finishes at the position. See Week 4 rankings.

Betting nugget: Allen seeks to be the second quarterback in the Super Bowl era to begin his career 3-0 despite being an underdog in each game. Patrick Mahomes is the other. Read more.

Newton’s pick: Texans 24, Panthers 21
Barshop’s pick: Texans 24, Panthers 16
FPI prediction: HOU, 75.4% (by an average of 9.5 points)

Matchup must-reads: Three NFL players from a tiny town of 300? Meet the Bassfield BoysToo soon for Kyle Allen to challenge Cam Newton like ‘Play 60’ kidWatt on sacks: ‘I knew it was just a matter of time’Olsen reestablishing himself as a top tight end

Raiders (1-2) at Colts (2-1)

1 p.m. ET | CBS
Matchup rating: 45.5 | Spread: IND -6.5 (45.5)

What to watch for: The Colts had eight sacks in their first two games of the season, but as pass-rusher Justin Houston noted, Atlanta’s Matt Ryan did a good job of getting a rid of the ball quickly to cause the Colts to go sackless in Week 3. Don’t be surprised if Derek Carr and the Raiders try to do the same thing Sunday. — Mike Wells